Review Article : The Effect of Quercetin Compounds on Type II Diabetes Mellitus
DOI:
https://doi.org/10.59890/ijels.v2i10.2430Keywords:
Diabetes Mellitus Type II, Quercetin, GlucoseAbstract
The immune system of the body targets the insulin-producing pancreatic cells, which results in diabetes mellitus. Synthesized antidiabetic drugs cause side effects of liver and kidney damage. Quercetin are known to have the same mechanism as synthetic antidiabetic drugs, so it can be an alternative treatment for diabetes. This article is a review with a literature search using PubMed, MDPI and Google Scholar. Quercetin activate AMPK which affects the decrease in blood glucose levels, protect cell damage due to free radicals so as to prevent a decrease in insulin levels and repair tissue damage due to hyperglycemia. Quercetin plays a role in reducing the risk of Type II DM complications. Quercetin compounds affect Type II Diabetes Mellitus with various mechanisms.
References
Abd Rahman, R., Jayasingh Chellammal, H. S., Ali Shah, S. A., Mohd Zohdi, R.,
Ramachandran, D., & Mohsin, H. F. (2024). Exploring the therapeutic potential of Derris elliptica (Wall.) Benth in Streptozotocin-Induced diabetic Rats: Phytochemical characterization and antidiabetic evaluation: Exploring the Therapeutic Potential of Derris elliptica (Wall.). Saudi Pharmaceutical Journal, 32(4), 102016. https://doi.org/10.1016/j.jsps.2024.102016
Adiputra, R. (2023). Efek Samping Penggunaan Obat Anti Diabetes Jangka Panjang : Sebuah Meta Analisis. 4(September), 3951–3959.
Alzahrani, M. A., Alsiary, K. A., Khan, M. A., Bushnaq, A., Alzahrani, B., Salama, M., & Alamri, N. S. (2019). Perception of Herbs Use in Treating Diabetes Among Patients Attending Specialized Polyclinics of National Guard Health Affairs, Jeddah. Journal of Family Medicine and Primary Care, 8(4), 270–275. https://doi.org/10.4103/jfmpc.jfmpc
Anand David, A. V., Arulmoli, R., & Parasuraman, S. (2016). Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacognosy Reviews, 10(20), 84–89. https://doi.org/10.4103/0973-7847.194044
Ansari, P., Choudhury, S. T., Seidel, V., Rahman, A. Bin, Aziz, M. A., Richi, A. E., Rahman, A., Jafrin, U. H., Hannan, J. M. A., & Abdel-Wahab, Y. H. A. (2022). Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus. Life, 12(8), 1–18. https://doi.org/10.3390/life12081146
Apriani, R., Kamaluddin, A. T., & Saleh, I. (2023). Mekanisme Aksi Quercetin dan Sensitizer Insulin Terhadap Peningkatan Sensitivitas Insulin. Oceana Biomedicina Journal, 6(2), 221–232. https://doi.org/10.30649/obj.v6i2.88
Authoria, N., Wijayanti, L., & Febrinasari, R. P. (2023). Efektivitas Quercetin dari Ekstrak Apel Lokal Terhadap Berat Badan dan Glukosa Darah Puasa Tikus Model Diabetes. Journal of The Indonesian Nutrition Association, 46(2), 171–180. https://doi.org/10.36457/gizindo.v46i2.847
Budianto, R. E., Linawati, N. M., Arijana, I. G. K. N., Wahyuniari, I. A. I., & Wiryawan, I. G. N. S. (2022). Potensi Senyawa Fitokimia pada Tumbuhan dalam Menurunkan Kadar Glukosa Darah pada Diabetes Melitus. Jurnal Sains dan Kesehatan, 4(5), 548–556. https://doi.org/10.25026/jsk.v4i5.1259
da Purificação, N. R. C., Garcia, V. B., Frez, F. C. V., Sehaber, C. C., Lima, K. R. D. A., de Oliveira Lima, M. F., de Carvalho Vasconcelos, R., de Araujo, A. A., de Araújo Júnior, R. F., Lacchini, S., de Oliveira, F., Perles, J. V. C. M., Zanoni, J. N.,
de Sousa Lopes, M. L. D., &
Clebis, N. K. (2022). Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats. Biomedicine and Pharmacotherapy, 151(May). https://doi.org/10.1016/j.biopha.2022.113131
Dhanya, R. (2022). Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Biomedicine and Pharmacotherapy, 146(December 2021), 112560. https://doi.org/10.1016/j.biopha.2021.112560
Fitriani, N.E, Akhmad, S.A, Lestariana, W. (2014). Efek Quercetin Terhadap Kadar Glukosa Darah Puasa Pada Tikus Diabetes Melitus Tipe 2 Yang Diinduksi Dengan Streptozotocin- Nicotinamide. Jurnal kedokteran dan kesehatan Indonesia, 6(2), 103–110. https://doi.org/10.20885/jkki.vol6.iss2.art7
Galicia-garcia, U., Benito-vicente, A., Jebari, S., & Larrea-sebal, A. (2020).
Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 1–34.
Hasibuan, N. K., Dur, S., & Husein, I. (2022). Faktor Penyebab Penyakit Diabetes Melitus dengan Metode Regresi Logistik. G-Tech: Jurnal Teknologi Terapan, 6(2), 257–264. https://doi.org/10.33379/gtech.v6i2.1696
Ikrima Rahmasari, E. S. W. (2019). Efektivitas Memordoca carantia (Pare) terhadap Penurunan Kadar Glukosa Darah. Infokes, 9(1), 57–64.
Iwara, I. A., Mboso, E. O., Eteng, O. E., Elot, K. N., Igile, G. O., & Ebong, P. E. (2022). Peristrophe bicalyculata extract and quercetin ameliorate high fat diet- streptozotocin-induced type ii diabetes in Wistar rats. Pharmacological Research - Modern Chinese Medicine, 2(January), 100060. https://doi.org/10.1016/j.prmcm.2022.100060
Jaishree, V., & Narsimha, S. (2020). Swertiamarin and quercetin combination ameliorates hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced type 2 diabetes mellitus in wistar rats. Biomedicine and Pharmacotherapy, 130(April), 110561. https://doi.org/10.1016/j.biopha.2020.110561
Kifle, Z. D., Bayleyegn, B., Yimer Tadesse, T., & Woldeyohanins, A. E. (2021). Prevalence and associated factors of herbal medicine use among adult diabetes mellitus patients at government hospital, Ethiopia: An institutional-based cross-sectional study. Metabolism Open, 11, 100120. https://doi.org/10.1016/j.metop.2021.100120
Kurup, S. B., & Mini, S. (2017). Averrhoa bilimbi fruits attenuate hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats. Journal of Food and Drug Analysis, 25(2), 360–368. https://doi.org/10.1016/j.jfda.2016.06.007
Lestari, L., & Zulkarnain, Z. (2021). (2023). Diabetes Melitus: Review etiologi, patofisiologi, gejala, penyebab, cara pemeriksaan, cara pengobatan dan cara pencegahan. Prosiding Seminar Nasional Biologi, 7(1), 237–241. Indonesian Journal of Nursing and Health Sciences, 4, 131–140.
Li, D., Jiang, C., Mei, G., Zhao, Y., Chen, L., Liu, J., Tang, Y., Gao, C., & Yao, P. (2020). Quercetin alleviates ferroptosis of pancreatic β cells in type 2 diabetes. Nutrients, 12(10), 1–15. https://doi.org/10.3390/nu12102954
Monika, A.M,Lestatriana, W. (2014). Pengaruh Pemberian Kombinasi Quercetin Dan Glibenklamid Terhadap Kadar Kolesterol Ldl Pada Tikus Diabetes Melitus Tipe 2. Jurnal kedokteran dan kesehatan Indonesia, 6(1), 28–37. https://doi.org/10.20885/jkki.vol6.iss1.art5
Petersmann, A., Nauck, M., Müller-Wieland, D., Kerner, W., Müller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. (2018). Definition, classification and diagnostics of diabetes mellitus. Journal of Laboratory Medicine, 42(3), 73–79. https://doi.org/10.1515/labmed-2018-0016
Putra, P. H., & Permana, D. (2022). Penggunaan Dan Pemilihan Obat Antidiabetes pada Pasien Diabetes Rawat Jalan di Puskesmas Karang Rejo Tarakan. Yarsi Journal of Pharmacology, 2(1), 38–45. https://doi.org/10.33476/yjp.v2i1.2197
Sagita, P., Apriliana, E., Mussabiq, S., & Soleha, T. (2020). Pengaruh pemberian daun sirsak terhadap penyakit diabetes. Jurnal Medika Hutama, 3(1), 1266–1272.
Sami, W., Ansari, T., Butt, N. S., Rashid, M., & Hamid, A. (2017). Effect Of Diet Counseling on Type 2 Diabetes Mellitus: A Review. International Journal of Health Sciences, 11(2), 65–71.
Srinivasan, P., Vijayakumar, S., Kothandaraman, S., & Palani, M. (2018). Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L. fruit: In silico and in vivo approaches. Journal of Pharmaceutical Analysis, 8(2), 109–118. https://doi.org/10.1016/j.jpha.2017.10.005
Vadila, A., Dody Izhar, M., & Suryani Nasution, H. (2021). Faktor-faktor Kejadian Diabetes Melitus Tipe 2 Di Puskesmas Putri Ayu. Media Kesehatan Politeknik Kesehatan Makassar, 16(2), 229–237.
Yang, D., Wang, T., Long, M., & Li, P. (2020). Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/8825387
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