Related of the Age, Body Mass Index and Anti-Müllerian Hormone with the Other Hormones in Polycystic Ovarian Syndrome Patients

Authors

  • Musafer Al-Ardi Ministry of Education, Iraq

DOI:

https://doi.org/10.59890/ijasr.v1i4.1047

Keywords:

Polycystic Ovarian Syndrome, AMH, BMI, Reproduction Hormones, Women Health

Abstract

Hormonal disorders affecting ageing and hormone levels significantly impact polycystic ovary syndrome (PCOS), which is linked to infertility. PCOS and obesity have a two-way overlap, affecting hormone concentrations with weight and age in PCOS-affected women. The study measured hormone concentrations in the blood serum of 62 POCS patients and found that BMI-related variables were negative with E2, insignificant negative association with HCG E2, Inhibin B, TSH, and FSH, insignificant positive association with prolactin LH, and age. Age-related variables were negative with AMH, HCG_E2, and prolactin, or positive with BMI, Inhibin, FSH, LH, and TSH, but insignificant. AMH changed positively with HCG E2, inhibin B, prolactin, and LH, and negatively with rest hormones. BMI is positively affected by a woman's age and PCOS, and age affects the production of inhibin, FSH, LH, and TSH. Therefore, the relationship between AMH and age is negative.

References

Guyton , A.C. and Hall, J. E. (2010). Textbook of Medical Physiology .11th edition.

Fowler , P.A. ; Sorsa, l. , ; Harris , W. ; and Mason, H.D. (2003) Ovarin gandotrophin surge at the hating factor( G.n.s.A.f) , J. of Reproduction .126 :689-699.

Broer, S. L.; Van Disseldorp, J.; Broeze, K. A.;Dolleman, M.; Opmeer, B. C.;

Bossuyt, P.; ijkemans, M. J. C.; Mol, B. -W. J.and et al. (2012). "Added value ofovarian reserve testing on patient characteristics in the production of ovarian response and ongoing pregnancy: An individual patient data approach". Human Reproduction Update19(1):26–36.

Fanchin R1, Schonäuer LM, Righini C, Frydman N, Frydman R, Taieb J,Comparison of Specificity and Sensitivity of AMH and FSH in Diagnosis of Premature Ovarian Failure,2003, PMCID: PMC4465760.

Kebbewar Molecular Diagnostic & Genetic Lab, by NCYHBG , April 2015.

Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in midlife: Implications for forecasting menopause. Hum Reprod. 1992;7:1342–6. Aziz ,R.; Woods K S, Reyna, R et al (2004). The prevalence and features of the polycystic ovary syndrome in an unseleted population, J. Clin Endocrinol and Metabol, 89(6): 2745- 2749 .

Essach, P. A ., Wickham E P & Nestler J. E.(2007). The metabolic Syndrome in polycystic ovary Syndrome . Clinical Obstetrics and Gynecology, 50:205-225.

Howard,S. and Jacobs,s(1995).(Poly Cystic Ovary Syndrome aetiology and management ) Current opinion inobestet and Gynecol, 7 :P: 203-208

Goldenberg , N., Glueck C. (2008). "Medical therapy in women with polycystic ovary syndrome before and during pregnancy and lactation". Minerva Ginecol 60 (1): 63–75. PMID 18277353

Norman, R.J.;Dewailly , D.; Legro , R.S .and Hickey, T.E. (2007). Polycystic ovary syndrome . Lancet , 37(9): 697-685 . Schroder, A.K.; Tauchert,S.,Ortmann, O.; Diedrich ,k. and Weiss ,J.M.(2004).Insulin resistence in patients with polycystic ovary syndrome. Ann.Med.,36(6): 426-439.

Al-Ardi, M.H. (2022). The Role of Hormones and Toxoplasma gondii Infection to Change the Secondary Sex Ratio. Iraqi Journal of Science, 63(7): 2850-2860.

Al-Ardi, M.H. (2021). The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual. Journal of medical & pharmaceutical Sciences, 5(1): 72-82.

Hoeger, K. M., Dokras, A., and Piltonen, T. (2021). Update on PCOS: consequences, challenges, and guiding treatment. The Journal of Clinical Endocrinology & Metabolism, 106(3): e1071-e1083.‏

Rudnicka, E., Suchta, K., Grymowicz, M., Calik-Ksepka, A., Smolarczyk, K., Duszewska, A. M., Meczekalski, B. (2021). Chronic low grade inflammation in pathogenesis of PCOS. International journal of molecular sciences, 22(7): 3789.‏

Barber, T. M., and Franks, S. (2021). Obesity and polycystic ovary syndrome. Clinical endocrinology, 95(4): 531-541.‏

Hu, L., Ma, L., Xia, X., Ying, T., Zhou, M., Zou, S., and Yin, J. (2022). Efficacy of bariatric surgery in the treatment of women with obesity and polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 107(8): e3217-e3229.‏

Kim, C. H., Chon, S. J., and Lee, S. H. (2020). Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: a systematic review and meta-analysis. Scientific reports, 10(1): 1-13.‏

Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Hunjan, T., Roberts, R., and Dhillo, W. S. (2019). Anti-müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome. Frontiers in endocrinology, 10: 656.‏

Park, Y. J., Shin, H., Jeon, S., Cho, I., and Kim, Y. J. (2021). Menstrual cycle patterns and the prevalence of premenstrual syndrome and polycystic ovary syndrome in Korean young adult women. In Healthcare ,Vol. 9( 1): p. 56.

Fatima, M., Amjad, S., Ali Sr, H. S., Ahmed, T., Khan, S., Raza, M., and Inam, M. (2020). Correlation of subclinical hypothyroidism with polycystic ovary syndrome (PCOS). Cureus, 12(5).‏

Raj, D., Pooja, F. N. U., Chhabria, P., Kalpana, F. N. U., Lohana, S., Lal, K., and Payal, F. N. U. (2021). Frequency of subclinical hypothyroidism in women with polycystic ovary syndrome. Cureus, 13(9).‏

Li, C., Xing, C., Zhang, J., Zhao, H., Shi, W., and He, B. (2021). Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. Journal of translational medicine, 19(1): 1-9.‏

Le, M. T., Le, V. N. S., Le, D. D., Nguyen, V. Q. H., Chen, C., and Cao, N. T. (2019). Exploration of the role of anti‐Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome. Clinical Endocrinology, 90(4), 579-585.‏

Khmil, M., Khmil, S., and Marushchak, M. (2020). Hormone imbalance in women with infertility caused by polycystic ovary syndrome: is there a connection with body mass index?. Open Access Macedonian Journal of Medical Sciences, 8(B), 731-737.‏

Garg, A., Patel, B., Abbara, A., and Dhillo, W. S. (2022). Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS). Clinical Endocrinology, 97(2): 156-164.‏

Szczuko, M., Kikut, J., Szczuko, U., Szydłowska, I., Nawrocka-Rutkowska, J., Ziętek, M., and Saso, L. (2021). Nutrition strategy and life style in polycystic ovary syndrome—Narrative review. Nutrients, 13(7): 2452.‏

Abbara, A., and Dhillo, W. S. (2021). Targeting elevated GnRH pulsatility to treat polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 106(10): e4275-e4277.‏

Zhu, J. L., Chen, Z., Feng, W. J., Long, S. L., and Mo, Z. C. (2019). Sex hormone-binding globulin and polycystic ovary syndrome. Clinica chimica acta, 499: 142-148.‏

Vaez, S., Parivr, K., Amidi, F., Rudbari, N. H., Moini, A., and Amini, N. (2023). Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. American Journal of Reproductive Immunology, 89(3): e13644.‏

Vural, F., Vural, B., Kardaş, E., Ertürk Coşkun, A. D., and Yildirim, İ. (2023). The diagnostic performance of antimullerian hormone for polycystic ovarian syndrome and polycystic ovarian morphology. Archives of Gynecology and Obstetrics, 307(4): 1083-1090.‏

He, Y., Wang, Q., Li, X., Wang, G., Zhao, J., Zhang, H., and Chen, W. (2020). Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota. Food & function, 11(6): 5192-5204.‏

Zhang, C., Liu, J., Lai, M., Li, J., Zhan, J., Wen, Q., and Ma, H. (2019). Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 300: 431-440.‏

Dewailly, D., Barbotin, A. L., Dumont, A., Catteau-Jonard, S., and Robin, G. (2020). Role of anti-Müllerian hormone in the pathogenesis of polycystic ovary syndrome. Frontiers in Endocrinology, 11: 641.‏

Bahri Khomami, M., Joham, A. E., Boyle, J. A., Piltonen, T., Silagy, M., Arora, C., and Moran, L. J. (2019). Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression. Obesity Reviews, 20(5): 659-674.‏

D'Alterio, M. N., Sigilli, M., Succu, A. G., Ghisu, V., Laganà, A. S., Sorrentino, F., and Angioni, S. (2021). Pregnancy outcomes in women with polycystic ovarian syndrome. Minerva Obstetrics and Gynecology, 74(1): 45-59.‏

Kelley, A. S., Smith, Y. R., and Padmanabhan, V. (2019). A narrative review of placental contribution to adverse pregnancy outcomes in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 104(11): 5299-5315.‏

Hu, S., Xu, B., Long, R., and Jin, L. (2021). The effect of polycystic ovary syndrome without hyperandrogenism on pregnancy‐related outcomes: a retrospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 128(6):1003-1010.‏

Yan, Q., Qiu, D., Liu, X., Xing, Q., Liu, R., & Hu, Y. (2022). The incidence of gestational diabetes mellitus among women with polycystic ovary syndrome: a meta-analysis of longitudinal studies. BMC Pregnancy and Childbirth, 22(1), 1-12.‏

Valdimarsdottir, R., Wikström, A. K., Kallak, T. K., Elenis, E., Axelsson, O., Preissl, H., and Poromaa, I. S. (2021). Pregnancy outcome in women with polycystic ovary syndrome in relation to second-trimester testosterone levels. Reproductive BioMedicine Online, 42(1): 217-225.‏

Liu, S., Mo, M., Xiao, S., Li, L., Hu, X., Hong, L., and Diao, L. (2020). Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Frontiers in Endocrinology, 11, 575337.‏

Debras, E., Fernandez, H., Neveu, M. E., Deffieux, X., and Capmas, P. (2019). Ovarian drilling in polycystic ovary syndrome: Long term pregnancy rate. European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 4, 100093.‏

Downloads

Published

2023-12-28

How to Cite

Al-Ardi, M. (2023). Related of the Age, Body Mass Index and Anti-Müllerian Hormone with the Other Hormones in Polycystic Ovarian Syndrome Patients. International Journal of Applied and Scientific Research, 1(4), 359–272. https://doi.org/10.59890/ijasr.v1i4.1047